Problem Back-up

I receive this message on the screen with the request to tranfer it to the support service.
What is to do? 

" System.IO.FileNotFoundException: Kan bestand C:\Users\Andre\Documents\eM Client\ niet vinden.
Bestandsnaam: C:\Users\Andre\Documents\eM Client\
   bij System.IO.__Error.WinIOError(Int32 errorCode, String maybeFullPath)
   bij System.IO.FileStream.Init(String path, FileMode mode, FileAccess access, Int32 rights, Boolean useRights, FileShare share, Int32 bufferSize, FileOptions options, SECURITY_ATTRIBUTES secAttrs, String msgPath, Boolean bFromProxy, Boolean useLongPath, Boolean checkHost)
   bij System.IO.FileStream…ctor(String path, FileMode mode, FileAccess access)
   bij MailClient.Storage.Backup.BackupCompressionTool…ctor(String backupDirectory)
   bij DbBackup.FormBackup.Backup(CancellationToken cancellationToken)
   bij DbBackup.FormBackup.<mainform_load>b__27_0(Object a, DoWorkEventArgs b)
bij System.ComponentModel.BackgroundWorker.OnDoWork(DoWorkEventArgs e)
bij System.ComponentModel.BackgroundWorker.WorkerThreadStart(Object argument)

Can you try doing the backup to another location such as a USB drive.