I never had much success with Wine because of the .NET dependency that eM Client has. It could be that I just did not setup .NET properly in Wine, then it just seemed to be such an endeavour to get it fixed. I did get it installed using CrossOver but occasionally got GTK warnings, and of course the application was not fully integrated in my GNOME desktop.
Linux Desktops have come a long way, and installing applications should be simple, which they are in most cases. You don’t really want to have to organize an install party just to get a single Windows application installed, and then after the next kernel update, find the whole thing is broken.
But if anyone has had recent success with Wine, or any other compatibility layer, I would be all ears and eyes. 
BTW Shaun, Wine is not an emulator. It is even in the acronym - Wine Is Not an Emulator. 