Recurring Gmail account problems

I normally connect to two Gmail accounts, always with the odd connectivity error, but never too serious. However over the last few weeks the problems have become chronic, particularly for whatever reason at weekends. No connection to the accounts, and no prospect of connection without a full pc reboot. So far this weekend no connection at all. I’m on the latest version, and take the automatic Gmail settings. Any clues as to the problem? Unfortunately it is starting to render em client unusable…