.NET Framework component problem

Suddenly today (19) I can not open MailClient due to C:\Windows\Microsoft.NET\Framework64\v4.0.30319\mscoreei.dll unable to be loaded. The DLL _is_ there, I can’t tell if anything happened to it, and the usual checking procedures Windows 10 provides, don’t show anything wrong.

Should I just back up my mail and re-install, or is there some other solution? Thanks.

Maybe a reinstall of .NET from Windows Update?

eM Client does not provide .NET itself, but you could uninstall eM Client, then reinstall it from the latest version available in the Release History. Just make sure to answer No to deleting the database folder during the uninstall. That way all your data and settings will still be there after the reinstall.