It's possible use a mark to know a mail has been responded?

I have been using outlook 2010 and when I respond an mail I see an arrow to know this mail was responded.

It’s possible setup same thing similar in emclient?

When you are using the conversation feature in eM Client, these indicators are not visible in the message list.

If you want to see them there, you can disable conversations using Menu > View > Conversations > Disable Conversations.