eM Client not connecting correctly on Start up

When I open eM Client for the 1st time after powering up the PC, I get the message ‘Connecting to “my email” failed’, however if I then follow the link to accounts and click of the Diagnostics tab and the Diagnose button, these come back as good and it starts working correctly.
It is not catastrophic, but blatantly something is not working as it should.
Any suggestions please?

Some things you can try:

  1. Disable your anti-virus application, then try again.

  2. Go to Menu > Tools > Accounts and check your settings.
    In the IMAP tab, check that you have one of the following combinations:
    Port 993 = Use SSL/TLS on special port (legacy)
    Port 143 = Use SSL/TLS if available