Yes, works for me:
I always use port 587 for SMTP, even if the default setup selects 465. The above screenshot is for my GMX.com account, but the same works for a number of others that I use.
But this may have to do with your email provider, or even your anti-virus/firewall application. Maybe temporarily disable the anti-virus, then try again. If you name the provider, maybe someone using them could comment.
If that still does not work, go to Menu > Operations and look for any SMTP errors in the Log tab.